Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size

Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size

Eukaryotic cells attempt to maintain an optimal size, resulting in size homeostasis. While cellular content scales isometrically with cell size, allometric laws indicate that metabolism per mass unit should decline with increasing size. Here we use elutriation and single-cell flow cytometry to analyze mitochondrial scaling with cell size. While mitochondrial content increases linearly, mitochon...

Allometry and size in ontogeny and phylogeny.

The allometry and scaling of the size of vertebrate eyes

We compiled data from the literature and colleagues to examine the relationship between eye axial length and body weight for vertebrates as well as birds, mammals, reptiles, and fishes independently. After fitting the data to logarithmic and semi-logarithmic models, we found that axial length of vertebrate eyes does obey a conventional logarithmic relationship with body weight rather than a sem...

A Review of Mitochondrial Biogenesis and Cellular Response

Abstract Background and Objectives Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover of this process. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly pla...

Cellular Allometry: The Spindle in Development and Inheritance

Recent studies have demonstrated a correlation between cell size and the behaviors of the cytoskeletal division machinery during embryogenesis, giving insight into how a core cellular process is modulated over the course of development.